Gout
Symptoms, Causes & Treatment
Everything you need to know about gout: what causes it, how to treat an acute attack, and how to prevent future attacks with urate-lowering therapy.
What Is Gout?
Gout is the most common inflammatory arthritis in the UK, affecting approximately 1 in 40 adults. It is caused by hyperuricaemia — excess uric acid in the blood — leading to the deposition of monosodium urate crystals in joints and periarticular tissue.
The typical presentation is sudden, excruciating pain in the big toe joint (first metatarsophalangeal joint) at night, with the joint becoming red, hot, swollen, and extraordinarily tender. Gout is entirely treatable and preventable with appropriate lifestyle modification and urate-lowering therapy.
Gout is not something to simply endure. With allopurinol and dietary changes, most people can become completely attack-free.
What Are the Symptoms of Gout?
Gout has a characteristic presentation that is often diagnosable on clinical grounds alone.
Sudden-onset excruciating pain in a single joint (usually big toe, ankle, or knee) · Joint red, hot, swollen, extremely tender to touch · Cannot bear weight · May have low-grade fever · Attacks typically resolve within 7–14 days without treatment
Gout with fever and confusion (possible septic arthritis requiring joint aspiration) · Tophi (urate deposits) causing joint destruction · Gout causing acute kidney injury · Allopurinol-induced severe skin reaction (SJS)
A hot, red, swollen joint with fever may be septic arthritis (not gout) and requires emergency joint aspiration. Never assume a hot joint is gout without clinical assessment — these conditions can coexist.
What Causes Gout?
Gout is caused by hyperuricaemia leading to monosodium urate crystal deposition in joints. Understanding the triggers and risk factors helps prevent recurrent attacks and long-term complications.
Gout is caused by hyperuricaemia (serum urate >360 μmol/L) leading to deposition of monosodium urate crystals in joints and periarticular tissue. Crystals trigger an intense neutrophilic inflammatory response producing the acute attack.
OA, RA, psoriatic arthritis, ankylosing spondylitis, and reactive arthritis have distinct pathological mechanisms and clinical presentations. Getting the correct diagnosis determines the appropriate treatment pathway and prevents disease progression.
Osteoarthritis (OA) causes progressive loss of articular cartilage, subchondral bone remodelling, and osteophyte formation. It is the most common cause of chronic joint pain in adults over 50, affecting knees, hips, hands, and spine.
Non-specific low back pain (no identifiable cause) accounts for 85% of presentations. Disc herniation, facet joint degeneration, and muscle/ligament strain are the most common structural causes. Poor posture and sedentary lifestyle are key contributors.
Rheumatoid arthritis (RA) is a systemic autoimmune disease in which the immune system attacks synovial joints, causing chronic synovitis, joint erosion, deformity, and systemic inflammation. Anti-CCP antibodies are highly specific.
Muscle strains occur when muscle fibres are overstretched or torn. Grade 1 = mild stretch; Grade 2 = partial tear; Grade 3 = complete rupture. Eccentric muscle loading during sprinting, jumping, or lifting is the most common mechanism.
Key Risk Factors
How Is Gout Diagnosed?
Gout is often diagnosed clinically in a classic presentation (sudden big toe pain in a middle-aged man). Joint aspiration with polarised light microscopy showing negatively birefringent urate crystals is definitive. Serum urate confirms hyperuricaemia but may be normal during an acute attack.
How Is Gout Treated?
Gout treatment has two phases: acute attack management (NSAIDs, colchicine, or prednisolone) and long-term urate lowering (allopurinol).
Supportive Measures
During an acute attack: elevate the joint, apply ice wrapped in a cloth, rest, and take analgesia as prescribed. Keep well hydrated. Do not start or stop allopurinol during an acute attack. Most attacks settle within 7–14 days.
Refractory Gout
Recurrent gout despite allopurinol requires dose optimisation (target urate <360 μmol/L). Febuxostat is an alternative for those intolerant of allopurinol. Chronic tophaceous gout with joint destruction requires rheumatology review. Pegloticase (IV uricase) is available for severe refractory cases.
When Should You Seek Medical Advice for Gout?
Joint pain with fever — possible septic arthritis which can coexist with gout and requires aspiration to exclude · Allopurinol-induced severe rash (SJS/TEN) — stop drug and attend A&E immediately.
First ever gout attack · Joint with fever (possible septic arthritis) · Gout not responding to first-line analgesia · More than 2 attacks in a year · Visible tophi or signs of joint destruction.
How to Prevent Gout Attacks
Gout is highly preventable with dietary modification and urate-lowering therapy. Most people can achieve complete freedom from attacks.
Reduce dietary purine intake: limit red meat, shellfish, organ meats, and beer. Stay well hydrated — 2–3 litres of water daily helps urate excretion. Reduce fructose-containing drinks and alcohol. Low-fat dairy products reduce urate levels.
Take allopurinol every day without stopping, even during gout attacks. Stopping and restarting allopurinol can precipitate acute attacks. Keep a urate-lowering diary and attend monitoring blood tests.
Weight management reduces load on weight-bearing joints. Every 1kg of body weight loss reduces knee joint loading by 4kg. Low-impact exercise (swimming, cycling) maintains fitness without joint stress.
Physiotherapy-led exercise is more effective than rest for most MSK conditions. Strengthening exercises for the muscles around affected joints reduce pain and improve function. Ask for a referral or self-refer where available.
Warm up adequately before exercise and cool down after. Increase training load gradually (the 10% rule). Strengthen muscles around vulnerable joints (glutes for knee, rotator cuff for shoulder, core for back) to reduce injury risk.
Know back pain red flags: bladder or bowel changes, saddle numbness, leg weakness, fever, unexplained weight loss, history of cancer. Any of these require same-day emergency assessment, not a routine appointment.
Speak to a Clinician About Gout
Through The GP Service, a licensed clinician can diagnose gout, prescribe acute treatment, initiate allopurinol, and monitor serum urate to target — all online without a waiting room.



Expert clinical advice, when you need it.
Gout FAQs
Gout attacks are caused by a sudden deposition of uric acid crystals in the joint. They are excruciatingly painful, typically beginning at night, affecting the big toe, ankle, or knee. Most attacks settle within 7–14 days. Short-term treatment with NSAIDs, colchicine, or prednisolone brings rapid relief. Urate-lowering therapy with allopurinol prevents recurrent attacks and is very effective. Gout is entirely manageable — it is not something that has to be simply endured.
Allopurinol should never be started during an acute gout attack as this can prolong or worsen the flare. It should be started 2–4 weeks after the acute attack has settled, ideally while continuing prophylactic colchicine or NSAID cover for the first 3–6 months. Start at 100mg daily and increase every 4 weeks to achieve a target serum urate below 360 μmol/L. Once on a stable dose, allopurinol is continued indefinitely. Stopping and restarting is a common cause of recurrent attacks.
Joint pain with a hot, red, severely swollen joint and fever is a red flag for septic arthritis — a surgical emergency. This requires same-day joint aspiration and IV antibiotics. Joint pain without these features requires investigation to determine the cause: OA, RA, gout, or reactive arthritis. Getting the right diagnosis quickly matters because RA causes joint erosion within weeks to months of onset, and early DMARD treatment dramatically reduces long-term disability.
OA affects cartilage and causes pain that worsens with use and eases with rest. RA is an autoimmune disease causing symmetrical synovial inflammation, morning stiffness >1 hour, systemic symptoms, and elevated inflammatory markers. RA gets worse without treatment and causes irreversible joint destruction; OA does not have systemic consequences. Getting the right diagnosis early is important because the treatments are completely different. If you have morning stiffness lasting over an hour and symmetrical joint swelling, see a clinician urgently for RA screening.
Most back pain is non-specific — caused by muscle, ligament, or disc strain without any serious underlying cause. The vast majority resolves within 4–6 weeks. Key red flags to watch for: bladder or bowel changes (possible cauda equina syndrome — call 999), fever, unexplained weight loss, or pain that is unrelenting at night regardless of position. If none of these are present, staying active, taking regular analgesia, and seeing a physiotherapist is the most effective approach.
Bed rest is not recommended and actually slows recovery. Staying as active as pain allows — walking, gentle stretching, swimming — helps the back heal faster. Most non-specific back pain improves within 4–6 weeks with movement, NSAIDs, and physiotherapy. Seeing a physiotherapist early produces better outcomes than waiting. If back pain has not improved after 6 weeks, or is worsening, a GP review is warranted to consider imaging and further management.
Sciatica is caused by compression of the sciatic nerve or its nerve roots — most commonly from a disc herniation at L4/5 or L5/S1. Around 80–90% of sciatica resolves within 6–12 weeks with conservative management: staying active, NSAIDs, physiotherapy, and nerve pain medication if needed. Red flags requiring emergency assessment: loss of bladder or bowel control, saddle numbness, or rapidly progressive leg weakness. These could indicate cauda equina syndrome, which is a surgical emergency.
Most rotator cuff problems — tendinopathy, partial tears, and impingement — respond well to physiotherapy. A targeted physiotherapy programme addressing rotator cuff strength and scapular control resolves 70–80% of cases within 3–6 months. Steroid injection provides short-term relief but does not improve long-term outcomes. Full-thickness rotator cuff tears with significant weakness warrant MRI assessment and possible surgical repair, especially in younger or active patients. Frozen shoulder runs a natural history of 1–3 years and usually resolves fully without surgery.
