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Gout

Symptoms, Causes & Treatment

Everything you need to know about gout: what causes it, how to treat an acute attack, and how to prevent future attacks with urate-lowering therapy.

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Easy and efficient! … I am on the mend and so glad this service exists.
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Excellent. Started to feel unwell and needed to see Dr before going on holiday. Couldn't get' GP appointment in time. I was 'seen' within 30mins of signing up. Just picked up a prescription. Very impressed with the Dr Victoria White.
Iann de Courcy
Fantastic service received from the gp service. Easy to book consultation… Would definitely use again :- )
Jay
Fantastic service. Easy to sign up and instructions were very clear. My doctor, Dr Shakil David Alam was amazing; listened to my issues, gave me in depth advice and really helped me out. Would definitely reuse - the speed of the service was impressive. Thank you Dr Shakil.
Babac Pashazadeh
I'm not someone who posts reviews regularly, but I have to say the process was super smooth. Booked a same day appointment with a clearly experienced and friendly doctor…
Yardie Grandmaster
Excellent service - quick, professional, and really convenient. The doctors are thorough and the whole process is smooth from start to finish. Highly recommend.
Mohammad Hassan
What our patients say
4.7 out of 5
Easy and efficient! … I am on the mend and so glad this service exists.
Pete Garvey
Excellent. Started to feel unwell and needed to see Dr before going on holiday. Couldn't get' GP appointment in time. I was 'seen' within 30mins of signing up. Just picked up a prescription. Very impressed with the Dr Victoria White.
Iann de Courcy
Fantastic service received from the gp service. Easy to book consultation… Would definitely use again :- )
Jay
Fantastic service. Easy to sign up and instructions were very clear. My doctor, Dr Shakil David Alam was amazing; listened to my issues, gave me in depth advice and really helped me out. Would definitely reuse - the speed of the service was impressive. Thank you Dr Shakil.
Babac Pashazadeh
I'm not someone who posts reviews regularly, but I have to say the process was super smooth. Booked a same day appointment with a clearly experienced and friendly doctor…
Yardie Grandmaster
Excellent service - quick, professional, and really convenient. The doctors are thorough and the whole process is smooth from start to finish. Highly recommend.
Mohammad Hassan
Overview

What Is Gout?

Gout is the most common inflammatory arthritis in the UK, affecting approximately 1 in 40 adults. It is caused by hyperuricaemia — excess uric acid in the blood — leading to the deposition of monosodium urate crystals in joints and periarticular tissue.

The typical presentation is sudden, excruciating pain in the big toe joint (first metatarsophalangeal joint) at night, with the joint becoming red, hot, swollen, and extraordinarily tender. Gout is entirely treatable and preventable with appropriate lifestyle modification and urate-lowering therapy.

Gout is not something to simply endure. With allopurinol and dietary changes, most people can become completely attack-free.

Symptoms

What Are the Symptoms of Gout?

Gout has a characteristic presentation that is often diagnosable on clinical grounds alone.

Gout Symptoms

Sudden-onset excruciating pain in a single joint (usually big toe, ankle, or knee) · Joint red, hot, swollen, extremely tender to touch · Cannot bear weight · May have low-grade fever · Attacks typically resolve within 7–14 days without treatment

common
Gout: When to Seek Urgent Help

Gout with fever and confusion (possible septic arthritis requiring joint aspiration) · Tophi (urate deposits) causing joint destruction · Gout causing acute kidney injury · Allopurinol-induced severe skin reaction (SJS)

serious
Gout vs Septic Arthritis — Know the Difference

A hot, red, swollen joint with fever may be septic arthritis (not gout) and requires emergency joint aspiration. Never assume a hot joint is gout without clinical assessment — these conditions can coexist.

Causes & Risk Factors

What Causes Gout?

Gout is caused by hyperuricaemia leading to monosodium urate crystal deposition in joints. Understanding the triggers and risk factors helps prevent recurrent attacks and long-term complications.

Gout: Urate Crystal Mechanism

Gout is caused by hyperuricaemia (serum urate >360 μmol/L) leading to deposition of monosodium urate crystals in joints and periarticular tissue. Crystals trigger an intense neutrophilic inflammatory response producing the acute attack.

Arthritis Classification

OA, RA, psoriatic arthritis, ankylosing spondylitis, and reactive arthritis have distinct pathological mechanisms and clinical presentations. Getting the correct diagnosis determines the appropriate treatment pathway and prevents disease progression.

Osteoarthritis Mechanism

Osteoarthritis (OA) causes progressive loss of articular cartilage, subchondral bone remodelling, and osteophyte formation. It is the most common cause of chronic joint pain in adults over 50, affecting knees, hips, hands, and spine.

Non-Specific Back Pain & Disc Disease

Non-specific low back pain (no identifiable cause) accounts for 85% of presentations. Disc herniation, facet joint degeneration, and muscle/ligament strain are the most common structural causes. Poor posture and sedentary lifestyle are key contributors.

Rheumatoid Arthritis Pathogenesis

Rheumatoid arthritis (RA) is a systemic autoimmune disease in which the immune system attacks synovial joints, causing chronic synovitis, joint erosion, deformity, and systemic inflammation. Anti-CCP antibodies are highly specific.

Muscle Strain Grades & Mechanism

Muscle strains occur when muscle fibres are overstretched or torn. Grade 1 = mild stretch; Grade 2 = partial tear; Grade 3 = complete rupture. Eccentric muscle loading during sprinting, jumping, or lifting is the most common mechanism.

Key Risk Factors

Hyperuricaemia (gout risk)
High purine diet (gout)
Diuretic use (gout)
Alcohol excess (gout)
Renal impairment (gout)
Obesity / high BMI
Age (degenerative changes)
Diabetes mellitus (frozen shoulder, neuropathy)
Corticosteroid use (tendon weakness)
Sedentary lifestyle & prolonged sitting
Poor posture and ergonomics
Family history of arthritis or back pain
Diagnosis

How Is Gout Diagnosed?

Gout is often diagnosed clinically in a classic presentation (sudden big toe pain in a middle-aged man). Joint aspiration with polarised light microscopy showing negatively birefringent urate crystals is definitive. Serum urate confirms hyperuricaemia but may be normal during an acute attack.

Test
What It Detects
When Used
Uric Acid (Serum Urate)
Hyperuricaemia (serum urate >360 μmol/L); guides allopurinol dose titration
Confirmed gout or suspected gout; monitoring urate-lowering therapy
Joint Aspiration (Arthrocentesis)
Septic arthritis (turbid fluid, organisms on Gram stain), gout (urate crystals), haemarthrosis
Hot, red, swollen joint with fever; suspected gout or pseudogout; diagnostic uncertainty
Rheumatoid Factor & Anti-CCP
Rheumatoid arthritis; anti-CCP is highly specific and predicts erosive disease
Suspected RA; symmetrical small joint polyarthritis with morning stiffness
Musculoskeletal Ultrasound
Soft tissue injury, tendon tears, effusions, rotator cuff tears, plantar fasciitis
Shoulder, Achilles, knee assessment; guided injection; soft tissue injury
X-ray (Peripheral Joints)
Fracture, joint space narrowing (OA), periarticular osteoporosis (RA), tophi (gout)
Trauma; suspected fracture; chronic joint disease assessment; Ottawa rules positive
Bone Density Scan (DEXA)
Osteoporosis (T-score <−2.5); fracture risk stratification; guides bisphosphonate prescribing
Postmenopausal women; men over 70; fracture; corticosteroid use; RA
Treatment Options

How Is Gout Treated?

Gout treatment has two phases: acute attack management (NSAIDs, colchicine, or prednisolone) and long-term urate lowering (allopurinol).

Antibiotic
Typical Use
Standard Course
Colchicine (Acute Gout)
Acute gout attack; alternative to NSAIDs when contraindicated; reduces inflammation within hours
500 micrograms 2–4 times daily until pain resolves (max 6mg per course); max 12 hours after first dose
Allopurinol (Gout Prevention)
Urate-lowering therapy for recurrent gout; never start during acute attack; lifelong
Start at 100mg daily; increase by 100mg every 4 weeks to target urate <360 μmol/L
NSAIDs (Ibuprofen, Naproxen)
First-line analgesia for musculoskeletal pain; acute gout; back pain; joint pain
Ibuprofen 400mg three times daily with food; naproxen 500mg twice daily; maximum 2 weeks continuous
Paracetamol
Baseline analgesia for MSK pain; used when NSAIDs contraindicated
500–1000mg up to four times daily; maximum 4g per day
Intra-articular Corticosteroid Injection
OA, frozen shoulder, knee effusion, gout — rapid short-term pain relief
Single injection; repeat maximum 3–4 times per year per joint
Physiotherapy & Exercise Therapy
Back pain, joint pain, sciatica, shoulder, knee — most effective treatment for chronic MSK conditions
6–12 weeks of structured physiotherapy; core strengthening, stretching, graded exercise

Supportive Measures

During an acute attack: elevate the joint, apply ice wrapped in a cloth, rest, and take analgesia as prescribed. Keep well hydrated. Do not start or stop allopurinol during an acute attack. Most attacks settle within 7–14 days.

Refractory Gout

Recurrent gout despite allopurinol requires dose optimisation (target urate <360 μmol/L). Febuxostat is an alternative for those intolerant of allopurinol. Chronic tophaceous gout with joint destruction requires rheumatology review. Pegloticase (IV uricase) is available for severe refractory cases.

When to Seek Help

When Should You Seek Medical Advice for Gout?

Seek Emergency Care (999 / A&E) If:

Joint pain with fever — possible septic arthritis which can coexist with gout and requires aspiration to exclude · Allopurinol-induced severe rash (SJS/TEN) — stop drug and attend A&E immediately.

See a Clinician the Same Day If:

First ever gout attack · Joint with fever (possible septic arthritis) · Gout not responding to first-line analgesia · More than 2 attacks in a year · Visible tophi or signs of joint destruction.

Prevention

How to Prevent Gout Attacks

Gout is highly preventable with dietary modification and urate-lowering therapy. Most people can achieve complete freedom from attacks.

Dietary Changes for Gout

Reduce dietary purine intake: limit red meat, shellfish, organ meats, and beer. Stay well hydrated — 2–3 litres of water daily helps urate excretion. Reduce fructose-containing drinks and alcohol. Low-fat dairy products reduce urate levels.

Adherence to Allopurinol

Take allopurinol every day without stopping, even during gout attacks. Stopping and restarting allopurinol can precipitate acute attacks. Keep a urate-lowering diary and attend monitoring blood tests.

Weight Management for Joint Health

Weight management reduces load on weight-bearing joints. Every 1kg of body weight loss reduces knee joint loading by 4kg. Low-impact exercise (swimming, cycling) maintains fitness without joint stress.

Exercise & Physiotherapy (Joint Pain)

Physiotherapy-led exercise is more effective than rest for most MSK conditions. Strengthening exercises for the muscles around affected joints reduce pain and improve function. Ask for a referral or self-refer where available.

Injury Prevention Through Warm-Up

Warm up adequately before exercise and cool down after. Increase training load gradually (the 10% rule). Strengthen muscles around vulnerable joints (glutes for knee, rotator cuff for shoulder, core for back) to reduce injury risk.

Know the Back Pain Red Flags

Know back pain red flags: bladder or bowel changes, saddle numbness, leg weakness, fever, unexplained weight loss, history of cancer. Any of these require same-day emergency assessment, not a routine appointment.

Getting Treatment

Speak to a Clinician About Gout

Through The GP Service, a licensed clinician can diagnose gout, prescribe acute treatment, initiate allopurinol, and monitor serum urate to target — all online without a waiting room.

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Frequently Asked Questions

Gout FAQs

How is a gout attack treated?

Gout attacks are caused by a sudden deposition of uric acid crystals in the joint. They are excruciatingly painful, typically beginning at night, affecting the big toe, ankle, or knee. Most attacks settle within 7–14 days. Short-term treatment with NSAIDs, colchicine, or prednisolone brings rapid relief. Urate-lowering therapy with allopurinol prevents recurrent attacks and is very effective. Gout is entirely manageable — it is not something that has to be simply endured.

When should I take allopurinol?

Allopurinol should never be started during an acute gout attack as this can prolong or worsen the flare. It should be started 2–4 weeks after the acute attack has settled, ideally while continuing prophylactic colchicine or NSAID cover for the first 3–6 months. Start at 100mg daily and increase every 4 weeks to achieve a target serum urate below 360 μmol/L. Once on a stable dose, allopurinol is continued indefinitely. Stopping and restarting is a common cause of recurrent attacks.

When is joint pain an emergency?

Joint pain with a hot, red, severely swollen joint and fever is a red flag for septic arthritis — a surgical emergency. This requires same-day joint aspiration and IV antibiotics. Joint pain without these features requires investigation to determine the cause: OA, RA, gout, or reactive arthritis. Getting the right diagnosis quickly matters because RA causes joint erosion within weeks to months of onset, and early DMARD treatment dramatically reduces long-term disability.

What is the difference between OA and RA?

OA affects cartilage and causes pain that worsens with use and eases with rest. RA is an autoimmune disease causing symmetrical synovial inflammation, morning stiffness >1 hour, systemic symptoms, and elevated inflammatory markers. RA gets worse without treatment and causes irreversible joint destruction; OA does not have systemic consequences. Getting the right diagnosis early is important because the treatments are completely different. If you have morning stiffness lasting over an hour and symmetrical joint swelling, see a clinician urgently for RA screening.

Is my back pain serious?

Most back pain is non-specific — caused by muscle, ligament, or disc strain without any serious underlying cause. The vast majority resolves within 4–6 weeks. Key red flags to watch for: bladder or bowel changes (possible cauda equina syndrome — call 999), fever, unexplained weight loss, or pain that is unrelenting at night regardless of position. If none of these are present, staying active, taking regular analgesia, and seeing a physiotherapist is the most effective approach.

How long does back pain last?

Bed rest is not recommended and actually slows recovery. Staying as active as pain allows — walking, gentle stretching, swimming — helps the back heal faster. Most non-specific back pain improves within 4–6 weeks with movement, NSAIDs, and physiotherapy. Seeing a physiotherapist early produces better outcomes than waiting. If back pain has not improved after 6 weeks, or is worsening, a GP review is warranted to consider imaging and further management.

Will sciatica get better on its own?

Sciatica is caused by compression of the sciatic nerve or its nerve roots — most commonly from a disc herniation at L4/5 or L5/S1. Around 80–90% of sciatica resolves within 6–12 weeks with conservative management: staying active, NSAIDs, physiotherapy, and nerve pain medication if needed. Red flags requiring emergency assessment: loss of bladder or bowel control, saddle numbness, or rapidly progressive leg weakness. These could indicate cauda equina syndrome, which is a surgical emergency.

Do I need surgery for my shoulder?

Most rotator cuff problems — tendinopathy, partial tears, and impingement — respond well to physiotherapy. A targeted physiotherapy programme addressing rotator cuff strength and scapular control resolves 70–80% of cases within 3–6 months. Steroid injection provides short-term relief but does not improve long-term outcomes. Full-thickness rotator cuff tears with significant weakness warrant MRI assessment and possible surgical repair, especially in younger or active patients. Frozen shoulder runs a natural history of 1–3 years and usually resolves fully without surgery.

Medical Disclaimer: The information on this page is provided for educational purposes only and is not intended as a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of a qualified healthcare professional with any questions you may have regarding a medical condition or medication. Never disregard professional medical advice or delay seeking it because of something you have read on this page. If you think you may have a medical emergency, call 999 or your local emergency services immediately.